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Peptide record

TPDB20056

Antibacterial Anticancer Antidiabetic Antifungal Toxicity standard

19 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB20056

Activity

Antibacterial Anticancer Antidiabetic Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia dbACP AFP-GFuse

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial, Anticancer, Antidiabetic, and other sources) peptide sequence curated from Peptipedia, dbACP, and AFP-GFuse, with an available 3D structural model.

Sequence

GIFKVLKNLAKGVITSLAS

FASTA

>TPDB20056|Antibacterial;Anticancer;Antidiabetic;Antifungal;Toxicity|length=19
GIFKVLKNLAKGVITSLAS

Formula C91H159N23O24

Absent Amino Acids RDCEQHMPWY

Common Amino Acids LK

Mass 1959.40

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +3

Boman Index 0.18

Hydrophobicity 0.889

Aliphatic Index 143.68

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

Amino Acid Distribution

A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 3 K: 3 M: 0 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 0 V: 2

Length

Formula

C91H159N23O24

Mass

1959.40

10.84

Net Charge

Boman Index

0.18

Hydrophobicity

0.889

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 25922 (MIC 1.56 uM), P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 25922 (MIC 1.56 uM), P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 3.12 uM), S. epid

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 25922 (MIC 1.56 uM), P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 3.12 uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. me

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

uM), P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 3.12 uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source NA

Other

Evidence Text

.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 3.12 uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 25922 (MIC 1.56 uM), P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli ATCC 25922 (MIC 1.56 uM), P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 3.12 uM), S. epid

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µM

Target

Target Organism A. baumannii ATCC 19606

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.12 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.56 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source NA

Other

Evidence Text

.56 uM), A. baumannii ATCC 19606 (MIC 1.56 uM), Gram+ S. aureus ATCC 25923 (MIC 3.12 uM), S. epidermidis ATCC 12228 (MIC 1.56 uM), B. megaterium BM11 (MIC Conlon et al., 2022 ).

Evidence 11 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 20±3 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 20±3 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Target Cell Human umbilical vein endothelial cells HUVEC

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs. | J Pept Sci | 2022

Evidence 12 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 107±8 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 107±8 | µM | target cell: Mouse erythrocytes

Target

Target Cell Mouse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial, cytotoxic, and insulin-releasing activities of the amphibian host-defense peptide ocellatin-3N and its L-lysine-substituted analogs. | J Pept Sci | 2022

Evidence 13 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

J Pept Sci. 2023 Apr 29(4):e3464.