TPDB

3D PDB MODEL

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TPDB ID TPDB20052

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

GIFGGHLKVGKKIACGLSGLC

FASTA

>TPDB20052|Antibacterial;Toxicity|length=21
GIFGGHLKVGKKIACGLSGLC

Formula C92H156N26O23S2

Absent Amino Acids RNDEQMPTWY

Common Amino Acids G

Mass 2058.53

PI 9.80

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +3

Boman Index 0.11

Hydrophobicity 0.767

Aliphatic Index 111.43

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.07

Polar Residues 3

number

1

A

0

R

0

N

0

D

2

C

0

E

0

Q

6

G

1

H

2

I

3

L

3

K

0

M

1

F

0

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 1 I: 2 L: 3 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

21

Formula

C92H156N26O23S2

Mass

2058.53

PI

9.80

Net Charge

+3

Boman Index

0.11

Hydrophobicity

0.767

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 32 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 32 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 32 ug/ml), S.enteritidis (MIC >128 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022