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Peptide record

TPDB19939

Antibacterial Anticancer Toxicity modified_plain modified
26 amino acids
Basic Information
3D PDB MODEL
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TPDB19939
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 26-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GIGAVXKVLTTGXPALISWXKRKRQQ
Physicochemical Analysis
C113H195N35O29
NDCEHMFY
GK
2508.01
12.43
5
0
9
+5
2.85
-0.192
90.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
219.30
5
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
2
I
2
L
3
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 2 L: 2 K: 3 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C113H195N35O29
2508.01
12.43
+5
2.85
-0.192
Evidence Records 2 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Substitution of the leucine zipper sequence in melittin with peptoid residues affects self-association, cell selectivity, and mode of action. | Biochim Biophys Acta | 2007
Evidence 2 Activity

Activity

0% Cytotoxicity
Toxicity
100 µM
Cytotoxic
0% Cytotoxicity | 100 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Substitution of the leucine zipper sequence in melittin with peptoid residues affects self-association, cell selectivity, and mode of action. | Biochim Biophys Acta | 2007