Back to search

Peptide record

TPDB19938

Antibacterial Antifungal Toxicity modified_plain modified
26 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB19938
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 26-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
GIGAVLXVLTTGLPALISWIXRXRQQ
Physicochemical Analysis
C113H192N32O29
NDCEHKMFY
L
2462.96
12.40
2
0
12
+2
-1.55
0.723
135.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
223.31
5
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
3
I
4
L
0
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 3 L: 4 K: 0 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C113H192N32O29
2462.96
12.40
+2
-1.55
0.723
Evidence Records 7 records
Evidence 1 Activity

Activity

0% Killing
Toxicity
500 µg/mL
Cytotoxic
0% Killing | 500 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin. | J Med Chem | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
10.49±2.65 µM
Cytotoxic
IC50 | 10.49±2.65 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Dimerization and lysine substitution of melittin have differing effects on bacteria | Front Pharmacol | 2024
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
1.4±1.14 µM
Hemolytic Cytotoxic
50% Hemolysis | 1.4±1.14 | µM | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Dimerization and lysine substitution of melittin have differing effects on bacteria | Front Pharmacol | 2024
Evidence 4 Activity

Activity

IC50
Toxicity
9.23±2.91 µM
Cytotoxic
IC50 | 9.23±2.91 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Dimerization and lysine substitution of melittin have differing effects on bacteria | Front Pharmacol | 2024
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
1.33±1.02 µM
Hemolytic Cytotoxic
50% Hemolysis | 1.33±1.02 | µM | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Dimerization and lysine substitution of melittin have differing effects on bacteria | Front Pharmacol | 2024
Evidence 6 Activity

Activity

IC50
Toxicity
14.32±6.02 µM
Cytotoxic
IC50 | 14.32±6.02 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Dimerization and lysine substitution of melittin have differing effects on bacteria | Front Pharmacol | 2024
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
0.89±0.39 µM
Hemolytic Cytotoxic
50% Hemolysis | 0.89±0.39 | µM | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Dimerization and lysine substitution of melittin have differing effects on bacteria | Front Pharmacol | 2024