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Peptide record

TPDB19928

Antibacterial Antifungal Toxicity modified_plain modified
26 amino acids
Basic Information
3D PDB MODEL
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TPDB19928
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 26-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
GIGAVLKVLTTGLPALISWIKRXRQQ
Physicochemical Analysis
C125H216N36O31
NDCEHMFY
L
2719.31
12.42
4
0
12
+4
0.43
0.423
135.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
202.26
5
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
2
Q
3
G
0
H
3
I
4
L
2
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 3 L: 4 K: 2 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C125H216N36O31
2719.31
12.42
+4
0.43
0.423
Evidence Records 1 records
Evidence 1 Activity

Activity

100% Killing
Toxicity
16 µg/mL
Cytotoxic
100% Killing | 16 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Rational Substitution of ε-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin. | J Med Chem | 2020