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Peptide record

TPDB19901

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB19901
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept dbAMP 3.0 AI4AVP DRAMP DRAVP 2.0 APD_complete APD_hemolytic Hemolytic2 ToxinPred 3.0
standard
No
A 33-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, iACP-DRLF, and other sources, with an available 3D structural model.
Sequence
GGTIFDCGETCFLGTCYTPGCSCGNYGFCYGTN
Physicochemical Analysis
C145H203N35O49S6
ARQHKMWV
G
3412.77
3.01
0
2
8
-2
-3.07
0.142
23.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
4845
141.97
17
Residue Composition
number
0
A
0
R
2
N
1
D
6
C
1
E
0
Q
8
G
0
H
1
I
1
L
0
K
0
M
3
F
1
P
1
S
5
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 1 C: 6 E: 1 Q: 0 G: 8 H: 0 I: 1 L: 1 K: 0 M: 0 F: 3 P: 1 S: 1 T: 5 W: 0 Y: 3 V: 0
Chemical Descriptors
33
C145H203N35O49S6
3412.77
3.01
-2
-3.07
0.142
Evidence Records 8 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 1.21 uM) and cytotoxicity (TC50 >3.5 uM), therapeutic index (4) (Ireland et al., 2008) . Cycloviolacins Y4 and Y5 are more hydrophobic (>50%) than cycloviolacin Y1 (33%), thereby more hemolytic.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

DRAMP Antifungipept

Other

It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 1.21 uM) and cytotoxicity (TC50 >3.5 uM), therapeutic index (4) (Ireland et al., 2008) . Cycloviolacins Y4 and Y5 are more hydrophobic (>50%) than cycloviolacin Y1 (33%), thereby more hemolytic.
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 1.21 uM) and cytotoxicity (TC50 >3.5 uM), therapeutic index (4) (Ireland et al., 2008) . Cycloviolacins Y4 and Y5 are more hydrophobic (>50%) than cycloviolacin Y1 (33%), thereby more hemolytic.
Evidence 4 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It inhibited HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells (EC50 1.21 uM) and cytotoxicity (TC50 >3.5 uM), therapeutic index (4) (Ireland et al., 2008) . Cycloviolacins Y4 and Y5 are more hydrophobic (>50%) than cycloviolacin Y1 (33%), thereby more hemolytic.
Evidence 5 Activity

Activity

Hemolysis
[Ref.18081258] It has hemolytic activity.

Source & Reference

APD_complete APD_hemolytic
DRAMP4
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.
Evidence 6 Activity

Activity

IC50
Toxicity
>4.5 µM
Cytotoxic
IC50 | >4.5 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis | J Nat Prod | 2008
Evidence 7 Activity

Activity

IC50
Toxicity
4470 nM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.18081258] It has hemolytic activity. | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50>4470 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.
Evidence 8 Hemolysis

Activity

[Ref.18081258] It has hemolytic activity.
Hemolysis

Source & Reference

APD_complete APD_hemolytic
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.
DRAMP4
APD_complete APD_hemolytic