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Peptide record

TPDB19868

Antibacterial Anticancer Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB19868
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 7-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GGYGPFP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C34H43N7O9
ARNDCEQHILKMSTWV
G
693.76
5.94
0
0
2
-0
-0.81
-0.414
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
2.15
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7 reviewed residue count
C34H43N7O9 sequence-only estimate (linear, free termini)
693.76 sequence-only estimate (linear, free termini)
5.94 sequence-only estimate (linear, free termini)
-0 sequence-only estimate (linear, free termini)
-0.81 sequence-only estimate (linear, free termini)
-0.414 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
3000 µM
Cytotoxic
IC50 | 3000 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Synthesis, structural aspects and cytotoxicity of the natural cyclopeptides yunnanins A, C and phakellistatins 1, 10 | Tetrahedron | 2003
Evidence 2 Activity

Activity

IC50
Toxicity
1700 µM
Cytotoxic
IC50 | 1700 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Cyclic peptides from higher plants. 24.1 yunnanin C, a novel cyclic heptapeptide from Stellaria yunnanensis. | J Nat Prod | 1996