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Peptide record

TPDB19862

Antibacterial Antifungal standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB19862
Antibacterial Antifungal
Anti-infective peptides
Peptipedia CAFPdb
standard
No
A 23-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
GFLDVLKGVGKAALGAVTHLINQ
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C106H177N29O29
RCEMPSWY
GL
2321.75
9.88
3
1
12
+1
-0.42
0.726
135.65
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
3
A
0
R
1
N
1
D
0
C
0
E
1
Q
4
G
1
H
1
I
4
L
2
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 4 H: 1 I: 1 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 3
Chemical Descriptors
23 reviewed residue count
C106H177N29O29 sequence-only estimate (linear, free termini)
2321.75 sequence-only estimate (linear, free termini)
9.88 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.42 sequence-only estimate (linear, free termini)
0.726 sequence-only estimate (linear, free termini)
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
27.5 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigote
Evidence 2 Activity

Activity

MIC
Antibacterial
27.5 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amast
Evidence 3 Activity

Activity

MIC
Antibacterial
55 µM

Target

Candida albicans

Source & Reference

NA

Other

Active against E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amastigotes (IC50 38.33 uM), P. fa
Evidence 4 Activity

Activity

IC50
Antibacterial
18.7 µM

Target

T. cruzi Trypomastigotes

Source & Reference

NA

Other

t E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amastigotes (IC50 38.33 uM), P. falciparum NF54 (IC50 36.82 uM) or TM90C2B (IC50 34.41
Evidence 5 Activity

Activity

IC50
Antibacterial
36.82 µM

Target

P. falciparum NF54

Source & Reference

NA

Other

5 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amastigotes (IC50 38.33 uM), P. falciparum NF54 (IC50 36.82 uM) or TM90C2B (IC50 34.41 uM), L. Mexicana (IC50 6.46 uM) ( Proaño-Bolaños et al., 2024 . Re
Evidence 6 Activity

Activity

IC50
Antibacterial
6.46 µM

Target

L. Mexicana

Source & Reference

NA

Other

astigotes (IC50 38.33 uM), P. falciparum NF54 (IC50 36.82 uM) or TM90C2B (IC50 34.41 uM), L. Mexicana (IC50 6.46 uM) ( Proaño-Bolaños et al., 2024 . Reg. 7/2021 updated 7/2024
Evidence 7 Activity

Activity

MIC
Antifungal
27.5 µM

Target

Escherichia coli

Source & Reference

CAFPdb

Other

Active against E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigote
Evidence 8 Activity

Activity

MIC
Antifungal
27.5 µM

Target

Staphylococcus aureus

Source & Reference

CAFPdb

Other

Active against E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amast
Evidence 9 Activity

Activity

MIC
Antifungal
55 µM

Target

Candida albicans

Source & Reference

CAFPdb

Other

Active against E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amastigotes (IC50 38.33 uM), P. fa
Evidence 10 Activity

Activity

IC50
Antifungal
18.7 µM

Target

T. cruzi Trypomastigotes

Source & Reference

CAFPdb

Other

t E. coli (MIC 27.5 uM), S. aureus (MIC 27.5 uM), and C. albicans (MIC 55 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amastigotes (IC50 38.33 uM), P. falciparum NF54 (IC50 36.82 uM) or TM90C2B (IC50 34.41
Evidence 11 Activity

Activity

IC50
Antifungal
36.82 µM

Target

P. falciparum NF54

Source & Reference

CAFPdb

Other

5 uM). Parasites: T. cruzi Trypomastigotes (IC50 18.7 uM) or Amastigotes (IC50 38.33 uM), P. falciparum NF54 (IC50 36.82 uM) or TM90C2B (IC50 34.41 uM), L. Mexicana (IC50 6.46 uM) ( Proaño-Bolaños et al., 2024 . Re
Evidence 12 Activity

Activity

IC50
Antifungal
6.46 µM

Target

L. Mexicana

Source & Reference

CAFPdb

Other

astigotes (IC50 38.33 uM), P. falciparum NF54 (IC50 36.82 uM) or TM90C2B (IC50 34.41 uM), L. Mexicana (IC50 6.46 uM) ( Proaño-Bolaños et al., 2024 . Reg. 7/2021 updated 7/2024