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Peptide record

TPDB19856

Antibacterial Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB19856
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.
Sequence
GFLDTLKNIGKTVGRIALNVLT
Physicochemical Analysis
C106H183N29O30
CEQHMPSWY
L
2343.80
10.59
3
1
10
+2
1.29
0.505
137.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
1
R
2
N
1
D
0
C
0
E
0
Q
3
G
0
H
2
I
4
L
2
K
0
M
1
F
0
P
0
S
3
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 1 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 4 K: 2 M: 0 F: 1 P: 0 S: 0 T: 3 W: 0 Y: 0 V: 2
Chemical Descriptors
22
C106H183N29O30
2343.80
10.59
+2
1.29
0.505
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.83 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 (MIC 6.83 uM), Gram+ S. aureus ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64
Evidence 2 Activity

Activity

MIC
Antibacterial
27.32 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 (MIC 6.83 uM), Gram+ S. aureus ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64 uM). Parasites: T. cruzi Trypomastigotes (I
Evidence 3 Activity

Activity

MIC
Antibacterial
54.64 µM

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

- E. coli ATCC 25922 (MIC 6.83 uM), Gram+ S. aureus ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.42 uM) or Amastigotes (IC50 30.16 uM), P. fa
Evidence 4 Activity

Activity

IC50
Antibacterial
1.42 µM

Target

T. cruzi Trypomastigotes

Source & Reference

NA

Other

s ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.42 uM) or Amastigotes (IC50 30.16 uM), P. falciparum NF54 (IC50 52.56 uM) or TM90C2B (IC50 24.87
Evidence 5 Activity

Activity

IC50
Antibacterial
52.56 µM

Target

P. falciparum NF54

Source & Reference

NA

Other

4 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.42 uM) or Amastigotes (IC50 30.16 uM), P. falciparum NF54 (IC50 52.56 uM) or TM90C2B (IC50 24.87 uM), L. Mexicana (IC50 0.1 uM) ( Proaño-Bolaños et al., 2024 ). Up
Evidence 6 Activity

Activity

IC50
Antibacterial
0.1 µM

Target

L. Mexicana

Source & Reference

NA

Other

astigotes (IC50 30.16 uM), P. falciparum NF54 (IC50 52.56 uM) or TM90C2B (IC50 24.87 uM), L. Mexicana (IC50 0.1 uM) ( Proaño-Bolaños et al., 2024 ). Updated 7/2024
Evidence 7 Activity

Activity

MIC
Antifungal
6.83 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 (MIC 6.83 uM), Gram+ S. aureus ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64
Evidence 8 Activity

Activity

MIC
Antifungal
27.32 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 (MIC 6.83 uM), Gram+ S. aureus ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64 uM). Parasites: T. cruzi Trypomastigotes (I
Evidence 9 Activity

Activity

MIC
Antifungal
54.64 µM

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

- E. coli ATCC 25922 (MIC 6.83 uM), Gram+ S. aureus ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.42 uM) or Amastigotes (IC50 30.16 uM), P. fa
Evidence 10 Activity

Activity

IC50
Antifungal
1.42 µM

Target

T. cruzi Trypomastigotes

Source & Reference

NA

Other

s ATCC 29213 (MIC 27.32 uM), and fungus C. albicans ATCC 10231 (MIC 54.64 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.42 uM) or Amastigotes (IC50 30.16 uM), P. falciparum NF54 (IC50 52.56 uM) or TM90C2B (IC50 24.87
Evidence 11 Activity

Activity

IC50
Antifungal
52.56 µM

Target

P. falciparum NF54

Source & Reference

NA

Other

4 uM). Parasites: T. cruzi Trypomastigotes (IC50 1.42 uM) or Amastigotes (IC50 30.16 uM), P. falciparum NF54 (IC50 52.56 uM) or TM90C2B (IC50 24.87 uM), L. Mexicana (IC50 0.1 uM) ( Proaño-Bolaños et al., 2024 ). Up
Evidence 12 Activity

Activity

IC50
Antifungal
0.1 µM

Target

L. Mexicana

Source & Reference

NA

Other

astigotes (IC50 30.16 uM), P. falciparum NF54 (IC50 52.56 uM) or TM90C2B (IC50 24.87 uM), L. Mexicana (IC50 0.1 uM) ( Proaño-Bolaños et al., 2024 ). Updated 7/2024
Evidence 13 Activity

Activity

61.6% Hemolysis
Toxicity
218.54 µM
Hemolytic Cytotoxic
61.6% Hemolysis | 218.54 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Picturins and Pictuseptins, two novel antimicrobial peptide families from the skin secretions of the Chachi treefrog, Boana picturata. | J Proteomics | 2022
Evidence 14 Activity

Activity

29.2% Hemolysis
Toxicity
54.64 µM
Hemolytic Cytotoxic
29.2% Hemolysis | 54.64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Picturins and Pictuseptins, two novel antimicrobial peptide families from the skin secretions of the Chachi treefrog, Boana picturata. | J Proteomics | 2022
Evidence 15 Activity

Activity

IC50
Toxicity
80.07 µM
Cytotoxic
IC50 | 80.07 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana, Plasmodium falciparum, and Trypanosoma cruzi | Microbiol Spectr | 2024