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Peptide record

TPDB19841

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19841
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GGKKLFKKILKYL
Physicochemical Analysis
C76H130N18O15
ARNDCEQHMPSTWV
K
1535.98
10.77
5
0
6
+5
0.91
-0.223
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
97.01
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
3
L
5
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C76H130N18O15
1535.98
10.77
+5
0.91
-0.223
Evidence Records 20 records
Evidence 1 Activity

Activity

IC50
Toxicity
57.9±6.4 µM
Cytotoxic
IC50 | 57.9±6.4 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 2 Activity

Activity

IC50
Toxicity
61.5±5.3 µM
Cytotoxic
IC50 | 61.5±5.3 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 3 Activity

Activity

7% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
7% Hemolysis | 160 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 4 Activity

Activity

9% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
9% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 5 Activity

Activity

IC50
Toxicity
60.5±7.6 µM
Cytotoxic
IC50 | 60.5±7.6 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 6 Activity

Activity

IC50
Toxicity
65.6±6.2 µM
Cytotoxic
IC50 | 65.6±6.2 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 7 Activity

Activity

12% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
12% Hemolysis | 160 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 8 Activity

Activity

15% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
15% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 9 Activity

Activity

IC50
Toxicity
55.7±3.2 µM
Cytotoxic
IC50 | 55.7±3.2 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 10 Activity

Activity

IC50
Toxicity
59.6±5.9 µM
Cytotoxic
IC50 | 59.6±5.9 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 11 Activity

Activity

18% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
18% Hemolysis | 160 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 12 Activity

Activity

22% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
22% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 13 Activity

Activity

IC50
Toxicity
49.4±5.7 µM
Cytotoxic
IC50 | 49.4±5.7 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 14 Activity

Activity

IC50
Toxicity
53.7±4.6 µM
Cytotoxic
IC50 | 53.7±4.6 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 15 Activity

Activity

23% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
23% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 16 Activity

Activity

IC50
Toxicity
40.1±3.6 µM
Cytotoxic
IC50 | 40.1±3.6 | µM | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 17 Activity

Activity

IC50
Toxicity
44.7±6.1 µM
Cytotoxic
IC50 | 44.7±6.1 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 18 Activity

Activity

20% Hemolysis
Toxicity
160 µM
Hemolytic Cytotoxic
20% Hemolysis | 160 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 19 Activity

Activity

28% Hemolysis
Toxicity
240 µM
Hemolytic Cytotoxic
28% Hemolysis | 240 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of novel aliphatic acid-conjugated antimicrobial peptides as potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. | Amino Acids | 2017
Evidence 20 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2017 Nov 49(11):1831-1841.