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Peptide record

TPDB19801

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19801
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
GFGMAXKLLKKVL
Physicochemical Analysis
C62H109N15O13S1
RNDCEQHIPSTWY
LK
1304.70
10.84
3
0
7
+3
-0.15
0.738
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
3
L
3
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 3 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C62H109N15O13S1
1304.70
10.84
+3
-0.15
0.738
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
93 µM
Hemolytic Cytotoxic
50% Hemolysis | 93 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 2 Activity

Activity

IC50
Toxicity
16 µM
Cytotoxic
IC50 | 16 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
19±2 µM
Cytotoxic
IC50 | 19±2 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
93 µM
Hemolytic Cytotoxic
50% Hemolysis | 93 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity study of macropin, a novel antimicrobial peptide from the venom of solitary bee Macropis fulvipes (Hymenoptera: Melittidae). | J Pept Sci | 2014
Evidence 5 Activity

Activity

IC50
Toxicity
93 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: IC50=93 µM | Cytotoxicity: HUVEC: IC50=16 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.