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Peptide record

TPDB19800

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19800
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
GFGMALXLLXXVL
Physicochemical Analysis
C50H84N10O11S1
RNDCEQHIKPSTWY
L
1033.34
6.02
0
0
8
-0
-3.68
1.931
150.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
4
L
0
K
1
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 4 K: 0 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C50H84N10O11S1
1033.34
6.02
-0
-3.68
1.931
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
262 µM
Hemolytic Cytotoxic
50% Hemolysis | 262 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 2 Activity

Activity

IC50
Toxicity
33±3 µM
Cytotoxic
IC50 | 33±3 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
43±5 µM
Cytotoxic
IC50 | 43±5 | µM | target cell: Rat epithelial cells IEC-6, CRL-1592

Target

Rat epithelial cells IEC-6, CRL-1592

Source & Reference

NA
DBAASP
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. | Peptides | 2012
Evidence 4 Activity

Activity

IC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: IC50>200 µM | Cytotoxicity: HUVEC: IC50=33±3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2012 Jan 33(1):18-26.