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Peptide record

TPDB19795

ACE inhibitor CLT-GG-SANMs dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Glycyl-glycine NDI-Gly-Gly or 4 OPA/GlyGly ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Toxicity iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB19795
ACE inhibitor CLT-GG-SANMs dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Glycyl-glycine NDI-Gly-Gly or 4 OPA/GlyGly
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Toxicity iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Toxicity and safety peptides Self-assembling and biomaterial peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
GG
Physicochemical Analysis
C4H8N2O3
ARNDCEQHILKMFPSTWYV
G
132.12
6.02
0
0
0
-0
0.02
-0.400
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C4H8N2O3
132.12
6.02
-0
0.02
-0.400
132.1176
132.0533
Self-Assembly Information 4 records
Record 1 Selfassembly

Source

25229206
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel
pH: 3.8 temperature: Room temperature solvent: Water concentration: 2% wt
Selfassembly; Nanostructure=Hydrogel; Trigger=pH: 3.8; temperature: Room temperature; solvent: Water; concentration: 2% wt
Transmission Electron Microscopy (TEM)
Selfassembly
Record 2 Selfassembly

Source

30354164
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticle nanoparticles
pH: 8.6 temperature: 40℃ solvent: 90% methanol aqueous solution concentration: 100ml
Selfassembly; Nanostructure=Nanoparticle; nanoparticles; Trigger=pH: 8.6; temperature: 40℃; solvent: 90% methanol aqueous solution; concentration: 100ml
NMR spectra,FTIR spectra, TEM, SEM
Selfassembly
Record 3 Selfassembly

Source

29138048
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticle Nanoparticles
Selfassembly; Nanostructure=Nanoparticle; Nanoparticles
Scanning Electron Microscopy (SEM)
Selfassembly
Record 4 Selfassembly

Source

29752121
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
nanomicelles
pH: 7.4 solvent: Clotrimazole, Glycine and ethylene glycol concentration: 0.025, 0.05, 0.1, 0.5, or 1.0 lg/m
Selfassembly; Nanostructure=nanomicelles; Trigger=pH: 7.4; solvent: Clotrimazole, Glycine and ethylene glycol; concentration: 0.025, 0.05, 0.1, 0.5, or 1.0 lg/m
Scanning Electron Microscopy (SEM)
Selfassembly
Evidence Records 11 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
7200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)NCC(=O)O InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9) InChIKey=YMAWOPBAYDPSLA-UHFFFAOYSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8783)
Evidence 2 Activity

Activity

IC50
Antihypertensive
7200.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cushman D. W.
Angiotensin converting enzyme inhibitors:Evolution of a new class of antihypertensive drugs (page 19). in: Horovitz Z. P. (Ed.)(1981), Mechanisms of action and clinical implications, Urban & Schwarzenberg.
1981
book

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)NCC(=O)O InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9) InChIKey=YMAWOPBAYDPSLA-UHFFFAOYSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8783)
Evidence 3 Activity

Activity

IC50
Toxicity
2.11±0.20 µM
Cytotoxic
IC50 | 2.11±0.20 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Searching for new derivatives of neocryptolepine: synthesis, antiproliferative, antimicrobial and antifungal activities. | Eur J Med Chem | 2014
Evidence 4 Activity

Activity

IC50
Toxicity
1.71±0.34 µM
Cytotoxic
IC50 | 1.71±0.34 | µM | target cell: Mouse fibroblasts BALB/3T3

Target

Mouse fibroblasts BALB/3T3

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. | J Med Chem | 2012
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
10% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthesis and biological evaluation of new amino acid and dipeptide derivatives of neocryptolepine as anticancer agents. | J Med Chem | 2012
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2012 Jun 14 55(11):5077-87.
Evidence 7 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)NCC(=O)O InChI=1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9) InChIKey=YMAWOPBAYDPSLA-UHFFFAOYSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database, BIOPEP-UWM database of bioactive peptides (ID 7616), the ChEMBL database, the DFBP database, the EROP-Moscow database
Evidence 8 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Trigger=pH: 3.8 temperature: Room temperature solvent: Water concentration: 2% wt
Hydrogel

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 3.8 temperature: Room temperature solvent: Water concentration: 2% wt
Transmission Electron Microscopy (TEM)
25229206
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 9 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticle nanoparticles Trigger=pH: 8.6 temperature: 40℃ solvent: 90% methanol aqueous solution concentration: 100ml
Nanoparticle nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 8.6 temperature: 40℃ solvent: 90% methanol aqueous solution concentration: 100ml
NMR spectra,FTIR spectra, TEM, SEM
30354164
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 10 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticle Nanoparticles
Nanoparticle Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
Scanning Electron Microscopy (SEM)
29138048
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 11 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=nanomicelles Trigger=pH: 7.4 solvent: Clotrimazole, Glycine and ethylene glycol concentration: 0.025, 0.05, 0.1, 0.5, or 1.0 lg/m
nanomicelles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.4 solvent: Clotrimazole, Glycine and ethylene glycol concentration: 0.025, 0.05, 0.1, 0.5, or 1.0 lg/m
Scanning Electron Microscopy (SEM)
29752121
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1665 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
pH: 3.8 temperature: Room temperature solvent: Water concentration: 2% wt pH: 8.6 temperature: 40℃ solvent: 90% methanol aqueous solution concentration: 100ml pH: 7.4 solvent: Clotrimazole, Glycine and ethylene glycol concentration: 0.025, 0.05, 0.1, 0.5, or 1.0 lg/m
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database. SAPdb ID 1665 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
2
25229206 30354164 29138048 29752121
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly