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Peptide record

TPDB19769

Antibacterial Anticancer Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB19769
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GFWARIGKVFAAVKNL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C86H133N23O18
DCEQHMPSTY
A
1777.15
11.64
3
0
10
+3
-0.05
0.637
103.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
3.09
1
Residue Composition
number
3
A
1
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
1
L
2
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 1 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
16 reviewed residue count
C86H133N23O18 sequence-only estimate (linear, free termini)
1777.15 sequence-only estimate (linear, free termini)
11.64 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.05 sequence-only estimate (linear, free termini)
0.637 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Designing Anticancer Peptides by Constructive Machine Learning. | ChemMedChem | 2018
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 400 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
ChemMedChem. 2018 Jul 6 13(13):1300-1302.