TPDB

3D PDB MODEL

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TPDB ID TPDB19741

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 44-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.

Sequence

GFGCPNDYSCSNHCRDSIGCRGGYCKYHVICTCYGCKKRRSIQE

FASTA

>TPDB19741|Antibacterial;Antifungal;Toxicity|length=44
GFGCPNDYSCSNHCRDSIGCRGGYCKYHVICTCYGCKKRRSIQE

Formula C205H316N66O63S8

Absent Amino Acids ALMW

Common Amino Acids C

Mass 4969.65

PI 8.30

Basic Residues 9

Acidic Residues 3

Hydrophobic Residues 9

Net Charge +4

Boman Index 7.53

Hydrophobicity -0.675

Aliphatic Index 33.18

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6460

Absorbance 280nm 129.99

Polar Residues 20

number

0

A

4

R

2

N

2

D

8

C

1

E

1

Q

6

G

2

H

3

I

0

L

3

K

0

M

1

F

1

P

4

S

1

T

0

W

4

Y

1

V

Amino Acid Distribution

A: 0 R: 4 N: 2 D: 2 C: 8 E: 1 Q: 1 G: 6 H: 2 I: 3 L: 0 K: 3 M: 0 F: 1 P: 1 S: 4 T: 1 W: 0 Y: 4 V: 1

Length

44

Formula

C205H316N66O63S8

Mass

4969.65

PI

8.30

Net Charge

+4

Boman Index

7.53

Hydrophobicity

-0.675

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6-12 µM

Target

Target Organism Staphylococcus aureus ATCC 6538

Source & Reference

Database Source NA

Other

Evidence Text

Active against GRam+ S. aureus ATCC 6538 (MIC 6-12 uM), M. luteus ATCC 4698 (MIC 1.5-3 uM), Gram- bacteria V. anguillarum DMC07, V. alginolyticu

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.5-3 µM

Target

Target Organism M. luteus ATCC 4698

Source & Reference

Database Source NA

Other

Evidence Text

Active against GRam+ S. aureus ATCC 6538 (MIC 6-12 uM), M. luteus ATCC 4698 (MIC 1.5-3 uM), Gram- bacteria V. anguillarum DMC07, V. alginolyticus DMC26, V. parahaemolyticus DMC18,

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6-12 µM

Target

Target Organism Staphylococcus aureus ATCC 6538

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against GRam+ S. aureus ATCC 6538 (MIC 6-12 uM), M. luteus ATCC 4698 (MIC 1.5-3 uM), Gram- bacteria V. anguillarum DMC07, V. alginolyticu

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.5-3 µM

Target

Target Organism M. luteus ATCC 4698

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against GRam+ S. aureus ATCC 6538 (MIC 6-12 uM), M. luteus ATCC 4698 (MIC 1.5-3 uM), Gram- bacteria V. anguillarum DMC07, V. alginolyticus DMC26, V. parahaemolyticus DMC18,