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Peptide record

TPDB19732

Antibacterial Antifungal standard
103 amino acids
Basic Information
3D PDB MODEL
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TPDB19732
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 103-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
GFFSFIGEAFQGAGDMWRAYTDMKEAGWKDGDKYFHARGNYDAAQRGPGGVWAAEKISDARESFQEFFGRGHEDTMADQEANRHGRSGKDPNYYRPPGLPAKY
Physicochemical Analysis
C516H739N149O155S3
C
G
11605.63
5.86
17
16
37
-2
23.05
-1.069
26.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
25440
219.20
19
Residue Composition
number
13
A
8
R
3
N
9
D
0
C
7
E
4
Q
15
G
3
H
2
I
1
L
6
K
3
M
8
F
5
P
4
S
2
T
3
W
6
Y
1
V
Amino Acid Distribution
A: 13 R: 8 N: 3 D: 9 C: 0 E: 7 Q: 4 G: 15 H: 3 I: 2 L: 1 K: 6 M: 3 F: 8 P: 5 S: 4 T: 2 W: 3 Y: 6 V: 1
Chemical Descriptors
103
C516H739N149O155S3
11605.63
5.86
-2
23.05
-1.069
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against E. coli and S. aureus at acidic pH 5.5. An incubation with 2.5 uM peptide reduced bacteria by 90%. Deletion of SAA1/2 in mice impaired the clearance of S. aureus in the skin. The bacterial killing of SAA at acidic pH was achieved via membrane binding and disruption ( Zheng et al., 2019 ).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against E. coli and S. aureus at acidic pH 5.5. An incubation with 2.5 uM peptide reduced bacteria by 90%. Deletion of SAA1/2 in mice impaired the clearance of S. aureus in the skin. The bacterial killing of SAA at acidic pH was achieved via membrane binding and disruption ( Zheng et al., 2019 ).