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Peptide record

TPDB19727

HFIAP-1 (1-18)[W7R,H12K,G14F] Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB19727
HFIAP-1 (1-18)[W7R,H12K,G14F]
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia DBAASP
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia and DBAASP, with an available 3D structural model.
Sequence
GFFKKARRKVKKAFRRVL
Physicochemical Analysis
C105H179N35O19
NDCEQHIMPSTWY
K
2235.80
12.89
9
0
8
+9
4.05
-0.761
65.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
5
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 5 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
18
C105H179N35O19
2235.80
12.89
+9
4.05
-0.761
Evidence Records 5 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 512 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
An active domain HF-18 derived from hagfish intestinal peptide effectively inhibited drug-resistant bacteria in vitro/vivo. | Biochem Pharmacol | 2020
Evidence 2 Activity

Activity

43% Killing
Toxicity
200 µg/mL
Cytotoxic
43% Killing | 200 | µg/mL | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
An active domain HF-18 derived from hagfish intestinal peptide effectively inhibited drug-resistant bacteria in vitro/vivo. | Biochem Pharmacol | 2020
Evidence 3 Activity

Activity

30% Killing
Toxicity
128 µg/mL
Cytotoxic
30% Killing | 128 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
An active domain HF-18 derived from hagfish intestinal peptide effectively inhibited drug-resistant bacteria in vitro/vivo. | Biochem Pharmacol | 2020
Evidence 4 Activity

Activity

10% Killing
Toxicity
128 µg/mL
Cytotoxic
10% Killing | 128 | µg/mL | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
An active domain HF-18 derived from hagfish intestinal peptide effectively inhibited drug-resistant bacteria in vitro/vivo. | Biochem Pharmacol | 2020
Evidence 5 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP