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Peptide record

TPDB19721

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Gly-DL-Phe NDI-Gly-Phe or 3 ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Neuropeptide iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB19721
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) Gly-DL-Phe NDI-Gly-Phe or 3
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Antiparasitic Antiviral Bitter Neuropeptide iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Neuroactive peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia SATPdb CAFPdb AHTPDB AHTpin Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, SATPdb, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GF
Physicochemical Analysis
C11H14N2O3
ARNDCEQHILKMPSTWYV
GF
222.24
6.02
0
0
1
-0
-1.12
1.200
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C11H14N2O3
222.24
6.02
-0
-1.12
1.200
222.2399
222.1001
Self-Assembly Information 2 records
Record 1 Selfassembly

Source

25229206
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Hydrogel
pH: 4.3 temperature: Room temperature solvent: Water concentration: 2% wt
Selfassembly; Nanostructure=Hydrogel; Trigger=pH: 4.3; temperature: Room temperature; solvent: Water; concentration: 2% wt
Transmission Electron Microscopy (TEM)
Selfassembly
Record 2 Selfassembly

Source

30348428
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanotube nanotubes
pH: 7.6
Selfassembly; Nanostructure=Nanotube; nanotubes; Trigger=pH: 7.6
Selfassembly
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
630.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@H](C(=O)O)Cc1ccccc1 InChI=1S/C11H14N2O3/c12-7-10(14)13-9(11(15)16)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)(H,15,16)/t9-/m0/s1 InChIKey: JBCLFWXMTIKCCB-VIFPVBQESA-N Inhibitor of cholecystokinin-8-inactivating peptidase (tripeptidyl-peptidase II) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database, the PubChem database Inhibitor of acylaminoacyl-peptidase (EC 3.4.19.1) (MEROPS ID: S09.004) according to the BRENDA database Inhibitor of dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID: 9488), the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8782) Antimalarial peptide according to the Parapep database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 19), the BitterDB database, the ChEMBL database, the EROP-Moscow database (ID E03703), the PubChem database Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 2 Activity

Activity

IC50
Antihypertensive
630.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Cheung H.-S., Wang F.-L., Ondetti M. A., Sabo E. F., Cushman D. W.
Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. J. Biol. Chem., 255, 401-407, 1980
1980
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@H](C(=O)O)Cc1ccccc1 InChI=1S/C11H14N2O3/c12-7-10(14)13-9(11(15)16)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)(H,15,16)/t9-/m0/s1 InChIKey: JBCLFWXMTIKCCB-VIFPVBQESA-N Inhibitor of cholecystokinin-8-inactivating peptidase (tripeptidyl-peptidase II) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database, the PubChem database Inhibitor of acylaminoacyl-peptidase (EC 3.4.19.1) (MEROPS ID: S09.004) according to the BRENDA database Inhibitor of dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID: 9488), the BRENDA database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8782) Antimalarial peptide according to the Parapep database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 19), the BitterDB database, the ChEMBL database, the EROP-Moscow database (ID E03703), the PubChem database Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001
Evidence 3 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: NCC(=O)N[C@H](C(=O)O)Cc1ccccc1 InChI=1S/C11H14N2O3/c12-7-10(14)13-9(11(15)16)6-8-4-2-1-3-5-8/h1-5,9H,6-7,12H2,(H,13,14)(H,15,16)/t9-/m0/s1 InChIKey: JBCLFWXMTIKCCB-VIFPVBQESA-N Inhibitor of cholecystokinin-8-inactivating peptidase (tripeptidyl-peptidase II) (EC 3.4.14.10) (MEROPS ID: S08.090) according to the BRENDA database, the PubChem database Inhibitor of acylaminoacyl-peptidase (EC 3.4.19.1) (MEROPS ID: S09.004) according to the BRENDA database Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 7591) the ChEMBL database Inhibitor of dipeptidyl-peptidase III (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9488), the BRENDA database Antimalarial peptide according to the ParaPep database Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 19), the BitterDB database, the ChEMBL database, the EROP-Moscow database (ID E03703), the PubChem database Information concerning Dipeptidyl peptidase IV (DPP IV) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/ ID: S09.003)
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Hydrogel Trigger=pH: 4.3 temperature: Room temperature solvent: Water concentration: 2% wt
Hydrogel

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 4.3 temperature: Room temperature solvent: Water concentration: 2% wt
Transmission Electron Microscopy (TEM)
25229206
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 5 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanotube nanotubes Trigger=pH: 7.6
Nanotube nanotubes

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.6
30348428
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 4.3 temperature: Room temperature solvent: Water concentration: 2% wt pH: 7.6
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
25229206 30348428
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly