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Peptide record

TPDB19711

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB19711
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GFCWYVCARRNGARVCYRRCN
Physicochemical Analysis
C108H165N39O26S4
DEQHILKMPST
R
2553.98
9.73
5
0
8
+5
-1.11
-0.429
37.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8730
341.82
8
Residue Composition
number
2
A
5
R
2
N
0
D
4
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
2
V
Amino Acid Distribution
A: 2 R: 5 N: 2 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 2
Chemical Descriptors
21
C108H165N39O26S4
2553.98
9.73
+5
-1.11
-0.429
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.0 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2-16.0 ug/ml), K. pneumonia (MIC 8.0 ug/ml), A. baumannii (MIC 4 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
2-16.0 µg/mL

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2-16.0 ug/ml), K. pneumonia (MIC 8.0 ug/ml), A. baumannii (MIC 4 ug/ml), E. faecium (MIC 16.0 ug/ml), S
Evidence 3 Activity

Activity

MIC
Antibacterial
8.0 µg/mL

Target

K. pneumonia

Source & Reference

NA

Other

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2-16.0 ug/ml), K. pneumonia (MIC 8.0 ug/ml), A. baumannii (MIC 4 ug/ml), E. faecium (MIC 16.0 ug/ml), S. aureus (MIC 8.0 ug/ml), and
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

A. baumannii

Source & Reference

NA

Other

E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2-16.0 ug/ml), K. pneumonia (MIC 8.0 ug/ml), A. baumannii (MIC 4 ug/ml), E. faecium (MIC 16.0 ug/ml), S. aureus (MIC 8.0 ug/ml), and C. acnes (MIC 63.0 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
16.0 µg/mL

Target

E. faecium

Source & Reference

NA

Other

aeruginosa (MIC 2-16.0 ug/ml), K. pneumonia (MIC 8.0 ug/ml), A. baumannii (MIC 4 ug/ml), E. faecium (MIC 16.0 ug/ml), S. aureus (MIC 8.0 ug/ml), and C. acnes (MIC 63.0 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
8.0 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

), K. pneumonia (MIC 8.0 ug/ml), A. baumannii (MIC 4 ug/ml), E. faecium (MIC 16.0 ug/ml), S. aureus (MIC 8.0 ug/ml), and C. acnes (MIC 63.0 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
63.0 µg/mL

Target

C. acnes

Source & Reference

NA

Other

, A. baumannii (MIC 4 ug/ml), E. faecium (MIC 16.0 ug/ml), S. aureus (MIC 8.0 ug/ml), and C. acnes (MIC 63.0 ug/ml).
Evidence 8 Activity

Activity

50% Cell death
Toxicity
>300 µg/mL
Cytotoxic
50% Cell death | >300 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Evidence 9 Activity

Activity

50% Cell death
Toxicity
>250 µg/mL
Cytotoxic
50% Cell death | >250 | µg/mL | target cell: Human kidney proximal tubule HK-2 cells

Target

Human kidney proximal tubule HK-2 cells

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 10 Activity

Activity

10% Hemolysis
Toxicity
>300 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 11 Activity

Activity

20% Hemolysis
Toxicity
18.8 ± 1.5 µg/mL
Hemolytic Cytotoxic
20% Hemolysis | 18.8 ± 1.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Investigations into the membrane activity of arenicin antimicrobial peptide AA139. | Biochim Biophys Acta | 2022
Evidence 12 Activity

Activity

<10% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<10% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel β-Hairpin Peptide from Marine Polychaeta with a High Efficacy against Gram-Negative Pathogens | Mar Drugs | 2022
Evidence 13 Activity

Activity

50% Cell death
Toxicity
128 µM
Cytotoxic
50% Cell death | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Novel β-Hairpin Peptide from Marine Polychaeta with a High Efficacy against Gram-Negative Pathogens | Mar Drugs | 2022