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Peptide record

TPDB19705

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB19705
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GFCWNVCVRRNGVRVCHRRCN
Physicochemical Analysis
C104H168N42O25S4
ADEQILKMPSTY
R
2534.98
10.72
6
0
6
+5
2.63
-0.395
55.24
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5750
226.83
7
Residue Composition
number
0
A
5
R
3
N
0
D
4
C
0
E
0
Q
2
G
1
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 5 N: 3 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 4
Chemical Descriptors
21
C104H168N42O25S4
2534.98
10.72
+5
2.63
-0.395
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.25 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 0.25 ug/ml) and K. pneumoniae BAA-2146 NDM-1 (MIC 4 ug/ml). Warning: other bacteria not tested.
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Klebsiella pneumoniae BAA-2146 NDM-1

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 0.25 ug/ml) and K. pneumoniae BAA-2146 NDM-1 (MIC 4 ug/ml). Warning: other bacteria not tested.
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>300 µg/mL
Cytotoxic
50% Cell death | >300 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 4 Activity

Activity

50% Cell death
Toxicity
>250 µg/mL
Cytotoxic
50% Cell death | >250 | µg/mL | target cell: Human kidney proximal tubule HK-2 cells

Target

Human kidney proximal tubule HK-2 cells

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
>300 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >300 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria. | Nat Commun | 2020