Back to search

Peptide record

TPDB19678

Antibacterial Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB19678
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GCVFLLPAKPHNYKKVFLSKGV
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C117H185N29O26S1
RDEQIMTW
K
2445.99
10.31
5
0
10
+4
-0.03
0.250
97.27
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
0.61
4
Residue Composition
number
1
A
0
R
1
N
0
D
1
C
0
E
0
Q
2
G
1
H
0
I
3
L
4
K
0
M
2
F
2
P
1
S
0
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 3 K: 4 M: 0 F: 2 P: 2 S: 1 T: 0 W: 0 Y: 1 V: 3
Chemical Descriptors
22 reviewed residue count
C117H185N29O26S1 sequence-only estimate (linear, free termini)
2445.99 sequence-only estimate (linear, free termini)
10.31 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.03 sequence-only estimate (linear, free termini)
0.250 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish. | Int J Mol Sci | 2022
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish. | Int J Mol Sci | 2022
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish. | Int J Mol Sci | 2022
Evidence 4 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish. | Int J Mol Sci | 2022