TPDB

3D PDB MODEL

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TPDB ID TPDB19670

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia AFP-GFuse Antifungipept CAFPdb

Sequence_Type

standard

Has_Modification No

Description A 24-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.

Sequence

GCSYSTRPYFLRWRLKFKSKVWCG

FASTA

>TPDB19670|Antibacterial;Antifungal|length=24
GCSYSTRPYFLRWRLKFKSKVWCG

Formula C139H206N38O31S2

Absent Amino Acids ANDEQHIM

Common Amino Acids RKS

Mass 2969.52

PI 10.55

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +6

Boman Index -2.97

Hydrophobicity -0.529

Aliphatic Index 44.58

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 14105

Absorbance 280nm 474.99

Polar Residues 8

number

0

A

3

R

0

N

0

D

2

C

0

E

0

Q

2

G

0

H

0

I

2

L

3

K

0

M

2

F

1

P

3

S

1

T

2

W

2

Y

1

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 3 M: 0 F: 2 P: 1 S: 3 T: 1 W: 2 Y: 2 V: 1

Length

24

Formula

C139H206N38O31S2

Mass

2969.52

PI

10.55

Net Charge

+6

Boman Index

-2.97

Hydrophobicity

-0.529

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 20-40 µM

Target

Target Organism M. maritypicum CIP 105733

Source & Reference

Database Source NA

Other

Evidence Text

Active against Gram+ B. stationis CIP: 101282 (MIC 20-40 uM), M. maritypicum CIP 105733 (MIC 20-40 uM), and fungi F. oxysporum (MIC 10-20 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10-20 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source NA

Other

Evidence Text

stationis CIP: 101282 (MIC 20-40 uM), M. maritypicum CIP 105733 (MIC 20-40 uM), and fungi F. oxysporum (MIC 10-20 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 20-40 µM

Target

Target Organism M. maritypicum CIP 105733

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

Active against Gram+ B. stationis CIP: 101282 (MIC 20-40 uM), M. maritypicum CIP 105733 (MIC 20-40 uM), and fungi F. oxysporum (MIC 10-20 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10-20 µM

Target

Target Organism F. oxysporum

Source & Reference

Database Source CAFPdb Antifungipept

Other

Evidence Text

stationis CIP: 101282 (MIC 20-40 uM), M. maritypicum CIP 105733 (MIC 20-40 uM), and fungi F. oxysporum (MIC 10-20 uM).