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Peptide record

TPDB19667

Antibacterial Anticancer Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB19667
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GARELRRLERELRRLEKGGGGGGKLAALTFEHYWAQLTSC
Physicochemical Analysis
C195H318N64O56S1
NDIMPV
GL
4487.13
10.19
9
5
14
+3
10.20
-0.677
78.25
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
155.78
6
Residue Composition
number
4
A
6
R
0
N
0
D
1
C
5
E
1
Q
7
G
1
H
0
I
7
L
2
K
0
M
1
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 1 E: 5 Q: 1 G: 7 H: 1 I: 0 L: 7 K: 2 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
40
C195H318N64O56S1
4487.13
10.19
+3
10.20
-0.677
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>64 µM
Cytotoxic
50% Cell death | >64 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>64 µM
Cytotoxic
50% Cell death | >64 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>64 µM
Cytotoxic
50% Cell death | >64 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>64 µM
Hemolytic Cytotoxic
50% Hemolysis | >64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>64 µM | Cytotoxicity: HFF-1: CC50>64 µM MCF-10A: CC50>64 µM Human PBMC: CC50>64 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2019 Sep 20 14(9):2071-2087.