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Peptide record

TPDB19666

Antibacterial Anticancer Toxicity standard
39 amino acids
Basic Information
3D PDB MODEL
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TPDB19666
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 39-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GARELRRLERELRRLEKGGGGGGKLAALKFKLLWLKLAC
Physicochemical Analysis
C195H337N63O48S1
NDQHIMPSTYV
L
4364.27
11.41
11
4
16
+7
8.46
-0.351
110.26
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
126.02
1
Residue Composition
number
4
A
6
R
0
N
0
D
1
C
4
E
0
Q
7
G
0
H
0
I
10
L
5
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 1 E: 4 Q: 0 G: 7 H: 0 I: 0 L: 10 K: 5 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
39
C195H337N63O48S1
4364.27
11.41
+7
8.46
-0.351
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
8.8±1.2 µM
Cytotoxic
50% Cell death | 8.8±1.2 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 2 Activity

Activity

50% Cell death
Toxicity
25.7±3.2 µM
Cytotoxic
50% Cell death | 25.7±3.2 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 3 Activity

Activity

50% Cell death
Toxicity
42.8±7.0 µM
Cytotoxic
50% Cell death | 42.8±7.0 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>64 µM
Hemolytic Cytotoxic
50% Hemolysis | >64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell Membrane Composition Drives Selectivity and Toxicity of Designed Cyclic Helix-Loop-Helix Peptides with Cell Penetrating and Tumor Suppressor Properties. | ACS Chem Biol | 2019
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>64 µM | Cytotoxicity: HFF-1: CC50=8.8 ± 1.2 µM MCF-10A: CC50=25.7 ± 3.2 µM Human PBMC: CC50=42.8 ± 7.0 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2019 Sep 20 14(9):2071-2087.