TPDB

3D PDB MODEL

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TPDB ID TPDB19661

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.

Sequence

GATIRAVNSR

FASTA

>TPDB19661|Antibacterial;Antifungal;Toxicity|length=10
GATIRAVNSR

Formula C42H77N17O14

Absent Amino Acids DCEQHLKMFPWY

Common Amino Acids AR

Mass 1044.18

PI 12.40

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 4

Net Charge +2

Boman Index 1.74

Hydrophobicity -0.210

Aliphatic Index 88.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

2

A

2

R

1

N

0

D

0

C

0

E

0

Q

1

G

0

H

1

I

0

L

0

K

0

M

0

F

0

P

1

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 2 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1

Length

10

Formula

C42H77N17O14

Mass

1044.18

PI

12.40

Net Charge

+2

Boman Index

1.74

Hydrophobicity

-0.210

Evidence 1 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 500 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 500 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthetic antimicrobial peptides: From choice of the best sequences to action mechanisms. | Biochimie | 2020

Evidence 2 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human fibroblasts MRC-5

Target

Target Cell Human fibroblasts MRC-5

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Synthetic antimicrobial peptides: From choice of the best sequences to action mechanisms. | Biochimie | 2020

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Mouse fibroblasts L929

Target

Target Cell Mouse fibroblasts L929

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022

Evidence 5 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Zebrafish embryos

Target

Target Cell Zebrafish embryos

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Neutralizing Effect of Synthetic Peptides toward SARS-CoV-2. | ACS Omega | 2022