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Peptide record

TPDB19657

Antibacterial Toxicity standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB19657
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 15-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GAFVLWGPTPRPRRR
Physicochemical Analysis
C81H128N28O17
NDCEQHIKMSY
R
1766.08
12.88
4
0
5
+4
1.11
-0.840
52.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
311.42
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
1
L
0
K
0
M
1
F
3
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 1 P: 3 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
15
C81H128N28O17
1766.08
12.88
+4
1.11
-0.840
Evidence Records 2 records
Evidence 1 Activity

Activity

MIC
Antibacterial
72.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

weakly active against E. coli ATCC 25922 (MIC 72.5 uM), S-enteritidis (MIC >72.5 uM), S-aureus ATCC 29213 (MIC > 72.5 uM).
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022