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Peptide record

TPDB19642

Longicalycinin A (Linear) Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB19642
Longicalycinin A (Linear)
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb dbAMP
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FYPFG
Physicochemical Analysis
C34H39N5O7
ARNDCEQHILKMSTWV
F
629.71
5.94
0
0
3
-0
-2.74
0.460
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
1490
236.62
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
2
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
5
C34H39N5O7
629.71
5.94
-0
-2.74
0.460
Free
L
Linear
Free
Anticancer
Synthetic
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
IC50 = 9.18 ± 0.0014 µg/ml
Anticancer
9.18

Target

Liver Cancer
HepG-2
Liver

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 9.61 ± 0.0007 µg/ml
Anticancer
9.61

Target

Colorectal Cancer
HT-29
Colon

Assay & Model

MTT assay
24-h

Source & Reference

CancerPPD 2.0
CancerPPD2
2020
Evidence 3 Activity

Activity

71.47% Cell death
Toxicity
100 µg/mL
Cytotoxic
71.47% Cell death | 100 | µg/mL | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Structure-activity relationship studies of Longicalcynin A analogues, as anticancer cyclopeptides. | Chem Biol Interact | 2020
Evidence 4 Activity

Activity

57.79% Cell death
Toxicity
100 µg/mL
Cytotoxic
57.79% Cell death | 100 | µg/mL | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Structure-activity relationship studies of Longicalcynin A analogues, as anticancer cyclopeptides. | Chem Biol Interact | 2020
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Interact. 2020 Jan 5 315:108918.