TPDB

3D PDB MODEL

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TPDB ID TPDB19603

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia CancerPPD 2.0

Sequence_Type

standard

Has_Modification No

Description A 22-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and CancerPPD 2.0, with an available 3D structural model.

Sequence

FWQRRIRRWRRFWQRRIRRWRR

FASTA

>TPDB19603|Antibacterial;Anticancer;Toxicity|length=22
FWQRRIRRWRRFWQRRIRRWRR

Formula C156H242N64O25

Absent Amino Acids ANDCEGHLKMPSTYV

Common Amino Acids R

Mass 3414.05

PI 13.44

Basic Residues 12

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +12

Boman Index 0.60

Hydrophobicity -2.273

Aliphatic Index 35.45

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 22000

Absorbance 280nm 644.40

Polar Residues 2

number

0

A

12

R

0

N

0

D

0

C

0

E

2

Q

0

G

0

H

2

I

0

L

0

K

0

M

2

F

0

P

0

S

0

T

4

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0

Length

22

Formula

C156H242N64O25

Mass

3414.05

PI

13.44

Net Charge

+12

Boman Index

0.60

Hydrophobicity

-2.273

Evidence 1 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 13.9±0.4 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 13.9±0.4 | µM | target cell: Human dermal fibroblasts

Target

Target Cell Human dermal fibroblasts

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. | Biochim Biophys Acta | 2015

Evidence 2 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 14.0±0.6 µM

Toxicity Type Cytotoxic

Toxicity Raw

LC50 | 14.0±0.6 | µM | target cell: Human epidermal melanocytes

Target

Target Cell Human epidermal melanocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. | Biochim Biophys Acta | 2015

Evidence 3 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 13.9

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: Not available | Cytotoxicity: Normal Human Dermal Fibroblasts (NHDF): LC50=13.9±0.4 µM

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochim Biophys Acta. 2015 Nov 1848(11 Pt A):2918-31.