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Peptide record

TPDB19602

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19602
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0 PD_Hemolysis ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
FWGTLAKWALKAI
Physicochemical Analysis
C76H113N17O15
RNDCEQHMPSYV
A
1504.84
10.60
2
0
9
+2
-4.64
0.738
113.08
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
730.98
1
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
2
K
0
M
1
F
0
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C76H113N17O15
1504.84
10.60
+2
-4.64
0.738
Evidence Records 4 records
Evidence 1 Activity

Activity

1.5% Hemolysis
Toxicity
2.5 µM
Hemolytic Cytotoxic
1.5% Hemolysis | 2.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 2 Activity

Activity

10.4% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
10.4% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 3 Activity

Activity

50% Cell death
Toxicity
144±75 µM
Cytotoxic
50% Cell death | 144±75 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
The dinoponeratoxin peptides from the giant ant Dinoponera quadriceps display in vitro antitrypanosomal activity. | Biol Chem | 2018
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis