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Peptide record

TPDB19601

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB19601
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP dbAMP 3.0 PD_Hemolysis ToxinPred 3.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
FWGTLAKWALK
Physicochemical Analysis
C67H97N15O13
RNDCEQHIMPSYV
ALKW
1320.60
10.60
2
0
7
+2
-4.16
0.300
89.09
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
11000
832.95
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
1
F
0
P
0
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
11
C67H97N15O13
1320.60
10.60
+2
-4.16
0.300
Evidence Records 3 records
Evidence 1 Activity

Activity

49.5% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
49.5% Hemolysis | 20 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antifungal In Vitro Activity of Pilosulin- and Ponericin-Like Peptides from the Giant Ant Dinoponera quadriceps and Synergistic Effects with Antimycotic Drugs. | Antibiotics (Basel) | 2020
Evidence 2 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
The dinoponeratoxin peptides from the giant ant Dinoponera quadriceps display in vitro antitrypanosomal activity. | Biol Chem | 2018
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis