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Peptide record

TPDB19587

ACE inhibitor FW Antibacterial Anticancer Antifungal Antihypertensive Bitter Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB19587
ACE inhibitor FW
Antibacterial Anticancer Antifungal Antihypertensive Bitter Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Food sensory peptides Self-assembling and biomaterial peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin Tastepeptides-Meta SAPdb
standard
No
A 2-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
FW
Physicochemical Analysis
C20H21N3O3
ARNDCEQGHILKMPSTYV
FW
351.41
6.02
0
0
2
-0
-2.98
0.950
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
1565.15
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
2
C20H21N3O3
351.41
6.02
-0
-2.98
0.950
351.3982
351.1578
Self-Assembly Information 2 records
Record 1 Selfassembly

Source

23795243
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanotube Tubes and aggregate
temperature: 30 °C solvent: Water concentration: 0.4M
Selfassembly; Nanostructure=Nanotube; Tubes and aggregate; Trigger=temperature: 30 °C; solvent: Water; concentration: 0.4M
Insilico method: MARTINI coarse - grained molecular dynamic
Selfassembly
Record 2 Selfassembly

Source

27841381
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanoparticles
Selfassembly; Nanostructure=Nanoparticles
TEM and SEM
Selfassembly
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Antihypertensive
0.00 µM
Inhibitor of Angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Rudolph S., Lunow D., Kaiser S., Henle T.
Identification and quantification of ACE-inhibiting peptides in enzymatic hydrolysates of plant proteins. Food Chem., 224, 19-25, 2017
2017
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=CC=C(C=C1))C(=O)N[C@@H](CC1=C[NH]C2=CC=CC=C12)C(=O)O InChI=1S/C20H21N3O3/c21-16(10-13-6-2-1-3-7-13)19(24)23-18(20(25)26)11-14-12-22-17-9-5-4-8-15(14)17/h1-9,12,16,18,22H,10-11,21H2,(H,23,24)(H,25,26)/t16-,18-/m0/s1 InChIKey=JMCOUWKXLXDERB-WMZOPIPTSA-N Inhibitor of Neprilysin (EC 3.4.24.11) (MEROPS ID: M13.008) according to the BRENDA database Development regulating peptide from hydra according to the EROP-Moscow database Hypouricemic peptide according to the BIOPEP-UWM database of bioactive peptides Bitter peptide according to the BIOPEP-UWM database of sensory peptides and amino acids (ID 339) the BitterDB database
Evidence 2 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanotube Tubes and aggregate Trigger=temperature: 30 °C solvent: Water concentration: 0.4M
Nanotube Tubes and aggregate

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
temperature: 30 °C solvent: Water concentration: 0.4M
Insilico method: MARTINI coarse - grained molecular dynamic
23795243
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Evidence 3 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanoparticles
Nanoparticles

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
TEM and SEM
27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID 1892 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
Additional Detail Fields 6 fields
temperature: 30 °C solvent: Water concentration: 0.4M
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database. SAPdb ID 1892 nanostr_class=Other but nanostr gives explicit morphology low-detail seed row.
2
23795243 27841381
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly