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Peptide record

TPDB19527

Antibacterial Toxicity modified_plain modified
28 amino acids
Basic Information
3D PDB MODEL
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TPDB19527
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 28-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
FTXAQWFAIQHISPXTIAMXAINNYXWX
Physicochemical Analysis
C130H183N31O32S1
RDCEGLKV
AI
2724.13
7.77
1
0
14
+0
-5.23
0.307
70.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
12490
458.49
8
Residue Composition
number
4
A
0
R
2
N
0
D
0
C
0
E
2
Q
0
G
1
H
4
I
0
L
0
K
1
M
2
F
1
P
1
S
2
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 4 L: 0 K: 0 M: 1 F: 2 P: 1 S: 1 T: 2 W: 2 Y: 1 V: 0
Chemical Descriptors
28
C130H183N31O32S1
2724.13
7.77
+0
-5.23
0.307
Evidence Records 2 records
Evidence 1 Activity

Activity

11±4% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
11±4% Hemolysis | 250 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021
Evidence 2 Activity

Activity

IC50
Toxicity
>300 µM
Cytotoxic
IC50 | >300 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Rationally Modified Antimicrobial Peptides from the N-Terminal Domain of Human RNase 3 Show Exceptional Serum Stability. | J Med Chem | 2021