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Peptide record

TPDB19483

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19483
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb
standard
No
A 13-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and CAFPdb, with an available 3D structural model.
Sequence
FKRILQRIKDFLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C81H137N25O17
ANCEGHMPSTWYV
R
1733.14
12.13
5
1
6
+4
3.42
-0.469
120.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13 reviewed residue count
C81H137N25O17 sequence-only estimate (linear, free termini)
1733.14 sequence-only estimate (linear, free termini)
12.13 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
3.42 sequence-only estimate (linear, free termini)
-0.469 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
76.8 µg/mL
Cytotoxic
IC50 | 76.8 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
160.9 µg/mL
Cytotoxic
IC50 | 160.9 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
76.8 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 500 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=76.8 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.
Evidence 5 Activity

Activity

IC50
Toxicity
160.9 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Not active up to 500 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=160.9 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.