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Peptide record

TPDB19447

Antibacterial Hemolysis Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB19447
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
FPFLLSLIPSAISALKKL
Physicochemical Analysis
C97H160N20O22
RNDCEQGHMTWYV
L
1958.46
10.60
2
0
11
+2
-2.75
1.322
162.78
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
5
L
2
K
0
M
2
F
2
P
3
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 5 K: 2 M: 0 F: 2 P: 2 S: 3 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C97H160N20O22
1958.46
10.60
+2
-2.75
1.322
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Staphylococcus aureus ATCC29213 or ATCC25923 or MRSA

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC29213 or ATCC25923 or MRSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 20 ug/ml), S. epidermidis (MIC 5-10 ug/ml), S. capitis (MIC 2
Evidence 2 Activity

Activity

MIC
Antibacterial
20 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC29213 or ATCC25923 or MRSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 20 ug/ml), S. epidermidis (MIC 5-10 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/
Evidence 3 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

us ATCC29213 or ATCC25923 or MRSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 20 ug/ml), S. epidermidis (MIC 5-10 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml), Gram- E. coli ATCC25922 or A
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5-5 µg/mL

Target

S. capitis

Source & Reference

NA

Other

(MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 20 ug/ml), S. epidermidis (MIC 5-10 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml), Gram- E. coli ATCC25922 or ATCC35218 (MIC 40-80 ug/ml), P-
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

S. intermedius

Source & Reference

NA

Other

ATCC29212 (MIC 20 ug/ml), S. epidermidis (MIC 5-10 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml), Gram- E. coli ATCC25922 or ATCC35218 (MIC 40-80 ug/ml), P-aeruginosa ATCC27853 (MIC>80 u
Evidence 6 Activity

Activity

MIC
Antibacterial
40-80 µg/mL

Target

Escherichia coli ATCC25922 or ATCC35218

Source & Reference

NA

Other

midis (MIC 5-10 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml), Gram- E. coli ATCC25922 or ATCC35218 (MIC 40-80 ug/ml), P-aeruginosa ATCC27853 (MIC>80 ug/ml), K-pneumoniae ATCC700603 (MIC > 80 ug/ml).
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
60 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 60 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two new cationic α-helical peptides identified from the venom gland of Liocheles australasiae possess antimicrobial activity against methicillin-resistant staphylococci. | Toxicon | 2021
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis