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Peptide record

TPDB19426

ACE inhibitor (BSA fr. 221-222) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-Phe-L-Pro ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Bitter Neuropeptide iDPPIV Selfassembly standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB19426
ACE inhibitor (BSA fr. 221-222) dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) L-Phe-L-Pro
ACE inhibitors Antibacterial Anticancer Antifungal Antihypertensive Bitter Neuropeptide iDPPIV Selfassembly
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Neuroactive peptides Food sensory peptides Self-assembling and biomaterial peptides
FermFooDB Peptipedia CAFPdb dbAMP AHTPDB AHTpin Tastepeptides-Meta iDPPIV SAPdb
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Anticancer, and other sources) peptide sequence curated from FermFooDB, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FP
Physicochemical Analysis
C14H18N2O3
ARNDCEQGHILKMSTWYV
FP
262.31
6.02
0
0
1
-0
-0.68
0.600
0.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C14H18N2O3
262.31
6.02
-0
-0.68
0.600
262.3036
262.1313
Self-Assembly Information 1 records
Record 1 Selfassembly

Source

30348428
10.1016/j.compbiomed.2021.104391
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly

Self-Assembly

Nanostructure formation
Nanotube nanotubes
pH: 7.6
Selfassembly; Nanostructure=Nanotube; nanotubes; Trigger=pH: 7.6
Selfassembly
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
315.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

FermFooDB
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J.Dairy Sci., 81(12) 3131-3138(1998)
1998
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccccc1 InChI=1S/C14H18N2O3/c15-11(9-10-5-2-1-3-6-10)13(17)16-8-4-7-12(16)14(18)19/h1-3,5-6,11-12H,4,7-9,15H2,(H,18,19)/t11-,12-/m0/s1 InChIKey: WEQJQNWXCSUVMA-RYUDHWBXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Found in amaranth (Amarantus hypochondriacus) proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8506) the BRENDA database the EROP-Moscow database Antifungal peptide according to the EROP-Moscow database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids the EROP-Moscow database
Evidence 2 Activity

Activity

IC50
Antihypertensive
315.00 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB FermFooDB
Abubakar A., Saito T., Kitazawa H., Kawai Y., Itoh T.
Structural analysis of new antihypertensive peptides derived from cheese whey protein by proteinase K digestion. J.Dairy Sci., 81(12) 3131-3138(1998)
1998
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccccc1 InChI=1S/C14H18N2O3/c15-11(9-10-5-2-1-3-6-10)13(17)16-8-4-7-12(16)14(18)19/h1-3,5-6,11-12H,4,7-9,15H2,(H,18,19)/t11-,12-/m0/s1 InChIKey: WEQJQNWXCSUVMA-RYUDHWBXSA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: XM02-001 Found in amaranth (Amarantus hypochondriacus) proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP database of bioactive peptides (ID 8506) the BRENDA database the EROP-Moscow database Antifungal peptide according to the EROP-Moscow database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids the EROP-Moscow database
Evidence 3 Activity

Activity

IC50
iDPPIV
363.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Hatanaka T., Inoue Y., Arima J., Kumagai Y., Usuki H., Kawakami K., Kimura M., Mukaihara T.
Production of dipeptidyl peptidase IV inhibitory peptides from defated rice bran. Food Chem., 134, 797-802
2012
Journal

Other

2
BIOPEP database of bioactive peptides SMILES: N[C@H](C(=O)N1[C@H](C(=O)O)CCC1)Cc1ccccc1 InChI=1S/C14H18N2O3/c15-11(9-10-5-2-1-3-6-10)13(17)16-8-4-7-12(16)14(18)19/h1-3,5-6,11-12H,4,7-9,15H2,(H,18,19)/t11-,12-/m0/s1 InChIKey: WEQJQNWXCSUVMA-RYUDHWBXSA-N Information concerning Dipeptidyl Peptidase IV (synonym: Dipeptidyl Aminopeptidase IV) (EC 3.4.14.5) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: S09.003 Peptide found in amaranth (Amarantus hypochondriacus) proteins: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: XM02-001) according to the AHTPDB database the BIOPEP database of bioactive peptides (ID 3502) the EROP-Moscow database Antifungal peptide according to the EROP-Moscow database Bitter peptide according to the BIOPEP database of sensory peptides and amino acids EROP-Moscow database
Evidence 4 Selfassembly

Activity

Nanostructure formation
Selfassembly Nanostructure=Nanotube nanotubes Trigger=pH: 7.6
Nanotube nanotubes

Source & Reference

SAPdb
10.1016/j.compbiomed.2021.104391

Other

None specified
pH: 7.6
30348428
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
Additional Detail Fields 6 fields
pH: 7.6
None specified
SAPdb ID NA low-detail seed row from experimentally curated self-assembly database.
2
30348428
SAPdb: A database of short peptides and the corresponding nanostructures formed by self-assembly