Back to search

Peptide record

TPDB19381

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB19381
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
FLSALWGVAKSLF
Physicochemical Analysis
C72H107N15O16
RNDCEQHIMPTY
L
1438.73
10.10
1
0
9
+1
-4.80
1.385
127.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
382.28
2
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
1
K
0
M
2
F
0
P
2
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 1 M: 0 F: 2 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C72H107N15O16
1438.73
10.10
+1
-4.80
1.385
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5-10 µg/mL

Target

Staphylococcus aureus ATCC29213 or ATCC25923 or MRSA

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC29213 or ATCC25923 or MRSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), S. epidermidis (MIC 5 ug/ml), S. capitis (MIC 2.5-
Evidence 2 Activity

Activity

MIC
Antibacterial
10 µg/mL

Target

Enterococcus faecalis ATCC29212

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC29213 or ATCC25923 or MRSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), S. epidermidis (MIC 5 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml)
Evidence 3 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

us ATCC29213 or ATCC25923 or MRSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), S. epidermidis (MIC 5 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml) including antibiotic-resistan
Evidence 4 Activity

Activity

MIC
Antibacterial
2.5-5 µg/mL

Target

S. capitis

Source & Reference

NA

Other

RSA (MIC 5-10 ug/ml), E. faecalis ATCC29212 (MIC 10 ug/ml), S. epidermidis (MIC 5 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml) including antibiotic-resistant strains, Gram- E. coli ATCC2
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

S. intermedius

Source & Reference

NA

Other

lis ATCC29212 (MIC 10 ug/ml), S. epidermidis (MIC 5 ug/ml), S. capitis (MIC 2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml) including antibiotic-resistant strains, Gram- E. coli ATCC25922 or ATCC35218 (MIC 20-80 u
Evidence 6 Activity

Activity

MIC
Antibacterial
20-80 µg/mL

Target

Escherichia coli ATCC25922 or ATCC35218

Source & Reference

NA

Other

2.5-5 ug/ml), S. intermedius (MIC 5 ug/ml) including antibiotic-resistant strains, Gram- E. coli ATCC25922 or ATCC35218 (MIC 20-80 ug/ml), P. aeruginosa ATCC27853 (MIC 80 ug/ml), K-pneumoniae ATCC700603 (MIC > 80 ug/ml).
Evidence 7 Activity

Activity

MIC
Antibacterial
80 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

NA

Other

ing antibiotic-resistant strains, Gram- E. coli ATCC25922 or ATCC35218 (MIC 20-80 ug/ml), P. aeruginosa ATCC27853 (MIC 80 ug/ml), K-pneumoniae ATCC700603 (MIC > 80 ug/ml).
Evidence 8 Activity

Activity

50% Hemolysis
Toxicity
45 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 45 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two new cationic α-helical peptides identified from the venom gland of Liocheles australasiae possess antimicrobial activity against methicillin-resistant staphylococci. | Toxicon | 2021
Evidence 9 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis