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Peptide record

TPDB19365

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19365
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FLQFWSKGVFRIL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C83H121N19O16
ANDCEHMPTY
F
1640.99
11.49
2
0
8
+2
-0.12
0.823
112.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
3.35
2
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
2
L
1
K
0
M
3
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 2 K: 1 M: 0 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13 reviewed residue count
C83H121N19O16 sequence-only estimate (linear, free termini)
1640.99 sequence-only estimate (linear, free termini)
11.49 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-0.12 sequence-only estimate (linear, free termini)
0.823 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

25% Cytotoxicity
Toxicity
24 µM
Cytotoxic
25% Cytotoxicity | 24 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Modulation of anti-endotoxin property of Temporin L by minor amino acid substitution in identified phenylalanine zipper sequence. | Biochem J | 2016