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Peptide record

TPDB19334

SSTP1 Antibacterial Anticancer Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB19334
SSTP1
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP
standard
No
A 18-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, CancerPPD 2.0, and dbACP, with an available 3D structural model.
Sequence
FLPLLISALTSLFPKLGK
Physicochemical Analysis
C97H160N20O22
RNDCEQHMWYV
L
1958.46
10.60
2
0
10
+2
-2.81
1.167
157.22
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
6
L
2
K
0
M
2
F
2
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 6 K: 2 M: 0 F: 2 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C97H160N20O22
1958.46
10.60
+2
-2.81
1.167
Free
L
Linear
Free
Host Defense Peptide
Indosylvirana aurantiaca
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
IC50 = 4.5 µM
Anticancer
4.5 µM

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
IC50 = 10.22 µM
Anticancer
10.22 µM

Target

Tongue Squamous Cell Carcinoma
HSC-4
Tongue

Assay & Model

MTT assay
48-h

Source & Reference

CancerPPD 2.0 dbACP
CancerPPD2
2021
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
50% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells. | Front Immunol | 2021
Evidence 4 Activity

Activity

IC50
Toxicity
21.72 µM
Cytotoxic
IC50 | 21.72 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells. | Front Immunol | 2021
Evidence 5 Activity

Activity

IC50
Toxicity
21.72 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human red blood cell: SSTP1-induced hemolysis at 5 µM was only-0.25% | Cytotoxicity: HEK293: IC50=21.72 µM, lower cytotoxicity

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Immunol. 2021 Nov 19 12:740620.