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Peptide record

TPDB19327

Antibacterial Anticancer Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB19327
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP Hemolytic2
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
FLPLLAGLAANFLPQIICKIARKC
Physicochemical Analysis
C123H205N31O27S2
DEHMSTWYV
L
2614.29
9.92
3
0
14
+3
-2.45
1.142
146.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.78
4
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
1
Q
1
G
0
H
3
I
5
L
2
K
0
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 5 K: 2 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C123H205N31O27S2
2614.29
9.92
+3
-2.45
1.142
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 32 uM), Gram- E.coli ATCC 8739 (MIC >512 uM), K.pneumoniae A
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 32 uM), Gram- E.coli ATCC 8739 (MIC >512 uM), K.pneumoniae ATCC 43816 (MIC >512 uM), P.aeruginos
Evidence 3 Activity

Activity

MIC
Antibacterial
>512 µM

Target

E.coli ATCC 8739

Source & Reference

NA

Other

ureus ATCC 6538 or MRSA NCTC 12493 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 32 uM), Gram- E.coli ATCC 8739 (MIC >512 uM), K.pneumoniae ATCC 43816 (MIC >512 uM), P.aeruginosa ATCC 9027 (MIC >512 uM)), C.albicans
Evidence 4 Activity

Activity

MIC
Antibacterial
>512 µM

Target

K.pneumoniae ATCC 43816

Source & Reference

NA

Other

93 (MIC 32 uM), E. faecalis NCTC 12697 (MIC 32 uM), Gram- E.coli ATCC 8739 (MIC >512 uM), K.pneumoniae ATCC 43816 (MIC >512 uM), P.aeruginosa ATCC 9027 (MIC >512 uM)), C.albicans ATCC 10231 (MIC >512 uM). It killed S.
Evidence 5 Activity

Activity

MIC
Antibacterial
>512 µM

Target

P.aeruginosa ATCC 9027

Source & Reference

NA

Other

(MIC 32 uM), Gram- E.coli ATCC 8739 (MIC >512 uM), K.pneumoniae ATCC 43816 (MIC >512 uM), P.aeruginosa ATCC 9027 (MIC >512 uM)), C.albicans ATCC 10231 (MIC >512 uM). It killed S. aureus at 2xMIC in 180 min. It also s
Evidence 6 Activity

Activity

MIC
Antibacterial
>512 µM

Target

C.albicans ATCC 10231

Source & Reference

NA

Other

C >512 uM), K.pneumoniae ATCC 43816 (MIC >512 uM), P.aeruginosa ATCC 9027 (MIC >512 uM)), C.albicans ATCC 10231 (MIC >512 uM). It killed S. aureus at 2xMIC in 180 min. It also showed biofilm inhibitory activity (MBI
Evidence 7 Activity

Activity

IC50
Toxicity
32.96 µM
Cytotoxic
IC50 | 32.96 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue. | Comput Struct Biotechnol J | 2023
Evidence 8 Activity

Activity

IC50
Toxicity
44.09 µM
Cytotoxic
IC50 | 44.09 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue. | Comput Struct Biotechnol J | 2023
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
23.96 µM
Hemolytic Cytotoxic
50% Hemolysis | 23.96 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue. | Comput Struct Biotechnol J | 2023
Evidence 10 Activity

Activity

IC50
Toxicity
32.96 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HMEC-1: IC50=32.96µM HaCaT: IC50=44.09µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Comput Struct Biotechnol J. 2023 May 6 21:2960-2972.