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Peptide record

TPDB19324

Antibacterial Anticancer Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB19324
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP Hemolytic2
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
FLPLLAGLAANFLPKIICKIARKC
Physicochemical Analysis
C124H209N31O26S2
DEQHMSTWYV
L
2614.34
10.32
4
0
14
+4
-2.04
1.125
146.67
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.78
3
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
5
L
3
K
0
M
2
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 5 K: 3 M: 0 F: 2 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C124H209N31O26S2
2614.34
10.32
+4
-2.04
1.125
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae AT
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa A
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

aureus ATCC 6538 or MRSA NCTC 12493 (MIC 8 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM)), C.albicans AT
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

NA

Other

12493 (MIC 8 uM), E. faecalis NCTC 12697 (MIC 16 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM)), C.albicans ATCC 10231 (MIC 256 uM). It killed S. a
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

697 (MIC 16 uM), Gram- E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM)), C.albicans ATCC 10231 (MIC 256 uM). It killed S. aureus at 2xMIC in 60 min. It also sho
Evidence 6 Activity

Activity

MIC
Antibacterial
256 µM

Target

C.albicans ATCC 10231

Source & Reference

NA

Other

39 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM)), C.albicans ATCC 10231 (MIC 256 uM). It killed S. aureus at 2xMIC in 60 min. It also showed biofilm inhibitory activity (MBIC
Evidence 7 Activity

Activity

IC50
Toxicity
26.45 µM
Cytotoxic
IC50 | 26.45 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue. | Comput Struct Biotechnol J | 2023
Evidence 8 Activity

Activity

IC50
Toxicity
20.53 µM
Cytotoxic
IC50 | 20.53 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue. | Comput Struct Biotechnol J | 2023
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
10.6 µM
Hemolytic Cytotoxic
50% Hemolysis | 10.6 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue. | Comput Struct Biotechnol J | 2023
Evidence 10 Activity

Activity

IC50
Toxicity
26.45 µM
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HMEC-1: IC50=26.45µM HaCaT: IC50=20.53µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Comput Struct Biotechnol J. 2023 May 6 21:2960-2973.