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Peptide record

TPDB19311

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19311
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
FLPLIGGLLKGLL
Physicochemical Analysis
C68H116N14O14
ARNDCEQHMSTWYV
L
1353.75
10.10
1
0
8
+1
-3.33
1.800
210.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
6
L
1
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 6 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C68H116N14O14
1353.75
10.10
+1
-3.33
1.800
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15.63 µg/mL

Target

L. monocytogenes

Source & Reference

NA

Other

active against L. monocytogenes (MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (
Evidence 2 Activity

Activity

MIC
Antibacterial
3.19 µg/mL

Target

B. subtilis

Source & Reference

NA

Other

active against L. monocytogenes (MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
3.91 µg/mL

Target

Staphylococcus aureus 9

Source & Reference

NA

Other

ive against L. monocytogenes (MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC 3.91 ug/ml), L. monocytogenes
Evidence 4 Activity

Activity

MIC
Antibacterial
7.81 µg/mL

Target

S. sciuri P254

Source & Reference

NA

Other

MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC 3.91 ug/ml), L. monocytogenes (MIC 1.95 ug/ml), Enterococcus E1
Evidence 5 Activity

Activity

MIC
Antibacterial
1.95 µg/mL

Target

L. monocytogenes

Source & Reference

NA

Other

(MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC 3.91 ug/ml), L. monocytogenes (MIC 1.95 ug/ml), Enterococcus E1478F (MIC 3.91 ug/ml), S. aureus RN4220 (MIC 3.91 ug/ml).
Evidence 6 Activity

Activity

MIC
Antibacterial
3.91 µg/mL

Target

Staphylococcus aureus RN4220

Source & Reference

NA

Other

MIC 3.91 ug/ml), L. monocytogenes (MIC 1.95 ug/ml), Enterococcus E1478F (MIC 3.91 ug/ml), S. aureus RN4220 (MIC 3.91 ug/ml).
Evidence 7 Activity

Activity

MIC
Antifungal
15.63 µg/mL

Target

L. monocytogenes

Source & Reference

CAFPdb

Other

active against L. monocytogenes (MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (
Evidence 8 Activity

Activity

MIC
Antifungal
3.19 µg/mL

Target

B. subtilis

Source & Reference

CAFPdb

Other

active against L. monocytogenes (MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC
Evidence 9 Activity

Activity

MIC
Antifungal
3.91 µg/mL

Target

Staphylococcus aureus 9

Source & Reference

CAFPdb

Other

ive against L. monocytogenes (MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC 3.91 ug/ml), L. monocytogenes
Evidence 10 Activity

Activity

MIC
Antifungal
7.81 µg/mL

Target

S. sciuri P254

Source & Reference

CAFPdb

Other

MIC 15.63 ug/ml), MDR strains B. subtilis (MIC 3.19 ug/ml), S. aureus 9 (MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC 3.91 ug/ml), L. monocytogenes (MIC 1.95 ug/ml), Enterococcus E1
Evidence 11 Activity

Activity

MIC
Antifungal
1.95 µg/mL

Target

L. monocytogenes

Source & Reference

CAFPdb

Other

(MIC 3.91 ug/ml), S. sciuri P254 (MIC 7.81 ug/ml), Streptococcus Sc181 (MIC 3.91 ug/ml), L. monocytogenes (MIC 1.95 ug/ml), Enterococcus E1478F (MIC 3.91 ug/ml), S. aureus RN4220 (MIC 3.91 ug/ml).
Evidence 12 Activity

Activity

MIC
Antifungal
3.91 µg/mL

Target

Staphylococcus aureus RN4220

Source & Reference

CAFPdb

Other

MIC 3.91 ug/ml), L. monocytogenes (MIC 1.95 ug/ml), Enterococcus E1478F (MIC 3.91 ug/ml), S. aureus RN4220 (MIC 3.91 ug/ml).
Evidence 13 Activity

Activity

≤5% Hemolysis
Toxicity
26.84±0.22 µg/mL
Hemolytic Cytotoxic
≤5% Hemolysis | 26.84±0.22 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation. | J Pept Sci | 2021
Evidence 14 Activity

Activity

≤5% Hemolysis
Toxicity
44.6±0.39 µg/mL
Hemolytic Cytotoxic
≤5% Hemolysis | 44.6±0.39 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation. | J Pept Sci | 2021