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Peptide record

TPDB19309

Antibacterial Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB19309
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Hemolytic2
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from Peptipedia and Hemolytic2, with an available 3D structural model.
Sequence
FLPLIAGVAAKVLPKIFCAISKKC
Physicochemical Analysis
C121H204N28O26S2
RNDEQHMTWY
AK
2531.24
10.17
4
0
14
+4
-0.89
1.296
138.33
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
4.94
3
Residue Composition
number
4
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
3
L
4
K
0
M
2
F
2
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 3 K: 4 M: 0 F: 2 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
24
C121H204N28O26S2
2531.24
10.17
+4
-0.89
1.296
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 µM

Target

Escherichia coli ATCC 35218

Source & Reference

NA

Other

active against E. coli ATCC 35218 (MIC 50 uM), S. aureus ATCC 12600 (MIC 3.13 uM), and E. faecium ATCC 19434 (MIC 6.25 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Staphylococcus aureus ATCC 12600

Source & Reference

NA

Other

active against E. coli ATCC 35218 (MIC 50 uM), S. aureus ATCC 12600 (MIC 3.13 uM), and E. faecium ATCC 19434 (MIC 6.25 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

E. faecium ATCC 19434

Source & Reference

NA

Other

active against E. coli ATCC 35218 (MIC 50 uM), S. aureus ATCC 12600 (MIC 3.13 uM), and E. faecium ATCC 19434 (MIC 6.25 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
4 µM
Hemolytic Cytotoxic
50% Hemolysis | 4 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic analysis of the host-defense peptides in skin secretions of the Amazon River frog Lithobates palmipes (Ranidae). | Comp Biochem Physiol Part D Genomics Proteomics | 2023