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Peptide record

TPDB19305

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB19305
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FLPLIAGKIFCAISKKC
Physicochemical Analysis
C88H146N20O19S2
RNDEQHMTWYV
IK
1852.37
9.80
3
0
9
+3
-1.57
1.224
126.47
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
6.75
3
Residue Composition
number
2
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
3
I
2
L
3
K
0
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 3 M: 0 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C88H146N20O19S2
1852.37
9.80
+3
-1.57
1.224
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Escherichia coli ATCC 35218

Source & Reference

NA

Other

active against E. coli ATCC 35218 (MIC 62.5 uM), S. aureus ATCC 12600 (MIC 31.3 uM), and E.faecium ATCC 19434 (MIC 125 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
31.3 µM

Target

Staphylococcus aureus ATCC 12600

Source & Reference

NA

Other

active against E. coli ATCC 35218 (MIC 62.5 uM), S. aureus ATCC 12600 (MIC 31.3 uM), and E.faecium ATCC 19434 (MIC 125 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
125 µM

Target

E.faecium ATCC 19434

Source & Reference

NA

Other

active against E. coli ATCC 35218 (MIC 62.5 uM), S. aureus ATCC 12600 (MIC 31.3 uM), and E.faecium ATCC 19434 (MIC 125 uM).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic analysis of the host-defense peptides in skin secretions of the Amazon River frog Lithobates palmipes (Ranidae). | Comp Biochem Physiol Part D Genomics Proteomics | 2023