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Peptide record

TPDB19243

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19243
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Hemolytic2
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from Peptipedia and Hemolytic2, with an available 3D structural model.
Sequence
FLPFLGKLLSGIF
Physicochemical Analysis
C75H114N14O15
ARNDCEQHMTWYV
L
1451.81
10.10
1
0
8
+1
-4.35
1.615
150.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
4
L
1
K
0
M
3
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 1 M: 0 F: 3 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C75H114N14O15
1451.81
10.10
+1
-4.35
1.615
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>250 µM

Target

E.coli ATCC 35218

Source & Reference

NA

Other

active against E.coli ATCC 35218 (MIC >250 uM) and S. aureus ATCC 12600 (MIC 15.6 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
15.6 µM

Target

Staphylococcus aureus ATCC 12600

Source & Reference

NA

Other

active against E.coli ATCC 35218 (MIC >250 uM) and S. aureus ATCC 12600 (MIC 15.6 uM).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
50% Hemolysis | 8 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic analysis of the host-defense peptides in skin secretions of the Amazon River frog Lithobates palmipes (Ranidae). | Comp Biochem Physiol Part D Genomics Proteomics | 2023
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
110 µM
Hemolytic Cytotoxic
50% Hemolysis | 110 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic analysis of the host-defense peptides in skin secretions of the Amazon River frog Lithobates palmipes (Ranidae). | Comp Biochem Physiol Part D Genomics Proteomics | 2023