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Peptide record

TPDB19222

Antibacterial Anticancer Antifungal Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB19222
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia Antifungipept
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
FLKAIKKFGKEFKKIGAKLK
Physicochemical Analysis
C114H192N28O23
RNDCQHMPSTWYV
K
2322.95
10.99
8
1
9
+7
4.49
-0.345
88.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
2
I
2
L
8
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 8 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C114H192N28O23
2322.95
10.99
+7
4.49
-0.345
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-32 µM

Target

Escherichia coli CRE or ESBL

Source & Reference

NA

Other

Active against E. coli CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >12
Evidence 2 Activity

Activity

MIC
Antibacterial
2-8 µM

Target

A. baumannii CRE

Source & Reference

NA

Other

Active against E. coli CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Klebsiella pneumoniae CRE

Source & Reference

NA

Other

Active against E. coli CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
>128 µM

Target

K.pneumoniae CRE

Source & Reference

NA

Other

CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (M
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Klebsiella pneumoniae ESBL

Source & Reference

NA

Other

umannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32
Evidence 6 Activity

Activity

MIC
Antibacterial
>128 µM

Target

K.pneumoniae strains

Source & Reference

NA

Other

umoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3
Evidence 7 Activity

Activity

MIC
Antibacterial
4-64 µM

Target

Pseudomonas aeruginosa CRE

Source & Reference

NA

Other

ae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM),
Evidence 8 Activity

Activity

MIC
Antibacterial
32-64 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

ae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM), and S. aureus MRSA (MIC 16 u
Evidence 9 Activity

Activity

MIC
Antibacterial
>128 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

oniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM), and S. aureus MRSA (MIC 16 uM), S.aureus strains MIC
Evidence 10 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus MRSA

Source & Reference

NA

Other

faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM), and S. aureus MRSA (MIC 16 uM), S.aureus strains MIC >128 uM). updated: 7/2021
Evidence 11 Activity

Activity

MIC
Antifungal
1-32 µM

Target

Escherichia coli CRE or ESBL

Source & Reference

Antifungipept

Other

Active against E. coli CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >12
Evidence 12 Activity

Activity

MIC
Antifungal
2-8 µM

Target

A. baumannii CRE

Source & Reference

Antifungipept

Other

Active against E. coli CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC
Evidence 13 Activity

Activity

MIC
Antifungal
4-8 µM

Target

Klebsiella pneumoniae CRE

Source & Reference

Antifungipept

Other

Active against E. coli CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MI
Evidence 14 Activity

Activity

MIC
Antifungal
>128 µM

Target

K.pneumoniae CRE

Source & Reference

Antifungipept

Other

CRE or ESBL (MIC 1-32 uM), A. baumannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (M
Evidence 15 Activity

Activity

MIC
Antifungal
16 µM

Target

Klebsiella pneumoniae ESBL

Source & Reference

Antifungipept

Other

umannii CRE (MIC 2-8 uM), K. pneumoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32
Evidence 16 Activity

Activity

MIC
Antifungal
>128 µM

Target

K.pneumoniae strains

Source & Reference

Antifungipept

Other

umoniae CRE (MIC 4-8 uM), K.pneumoniae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3
Evidence 17 Activity

Activity

MIC
Antifungal
4-64 µM

Target

Pseudomonas aeruginosa CRE

Source & Reference

Antifungipept

Other

ae CRE (MIC >128 uM), K. pneumoniae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM),
Evidence 18 Activity

Activity

MIC
Antifungal
32-64 µM

Target

Enterococcus faecalis

Source & Reference

Antifungipept

Other

ae ESBL (MIC 16 uM), K.pneumoniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM), and S. aureus MRSA (MIC 16 u
Evidence 19 Activity

Activity

MIC
Antifungal
>128 µM

Target

Enterococcus faecalis

Source & Reference

Antifungipept

Other

oniae strains (MIC >128 uM), P. aeruginosa CRE (MIC 4-64 uM), E. faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM), and S. aureus MRSA (MIC 16 uM), S.aureus strains MIC
Evidence 20 Activity

Activity

MIC
Antifungal
16 µM

Target

Staphylococcus aureus MRSA

Source & Reference

Antifungipept

Other

faecalis (MIC 32-64 uM), E.faecalis (MIC>128 uM), 3 E.faecalis strains MIC >128 uM), and S. aureus MRSA (MIC 16 uM), S.aureus strains MIC >128 uM). updated: 7/2021
Evidence 21 Activity

Activity

10% Killing
Toxicity
128 µg/mL
Cytotoxic
10% Killing | 128 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Ω76: A designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii. | Sci Adv | 2019
Evidence 22 Activity

Activity

1.78% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
1.78% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Ω76: A designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii. | Sci Adv | 2019
Evidence 23 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Adv. 2019 Jul 24 5(7):eaax1947.