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Peptide record

TPDB19214

Antibacterial Anticancer Antiviral Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB19214
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0 DRAMP DRAVP 2.0
standard
No
A 9-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLHFLHHLF
Physicochemical Analysis
C63H83N15O10
ARNDCEQGIKMPSTWYV
HLF
1210.45
8.09
3
0
6
+0
-2.19
1.133
130.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
3
L
0
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 3 K: 0 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C63H83N15O10
1210.45
8.09
+0
-2.19
1.133
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

DRAMP

Other

inhibit hepatitis C virus (HCV) infection (EC50 0.85 ug/ml).
Evidence 2 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
inhibit hepatitis C virus (HCV) infection (EC50 0.85 ug/ml).
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
416.4 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 416.4 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. | Biomaterials | 2013
Evidence 4 Activity

Activity

HC50
Toxicity
416.4 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.23415044] HC50 = 416.4 µg/ml against human red blood cells. | Cytotoxicity: [Ref.23415044] CC50>500 µg/ml against Huh7.5.1 cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomaterials. 2013 Apr 34(13):3511-22.