TPDB

3D PDB MODEL

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TPDB ID TPDB19184

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 19-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.

Sequence

FLGALIPAIAGAIGGLIRK

FASTA

>TPDB19184|Antibacterial;Toxicity|length=19
FLGALIPAIAGAIGGLIRK

Formula C88H151N23O20

Absent Amino Acids NDCEQHMSTWYV

Common Amino Acids AGI

Mass 1851.31

PI 11.49

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 12

Net Charge +2

Boman Index -2.44

Hydrophobicity 1.463

Aliphatic Index 164.74

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

4

A

1

R

0

N

0

D

0

C

0

E

0

Q

4

G

0

H

4

I

3

L

1

K

0

M

1

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 4 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 4 L: 3 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

19

Formula

C88H151N23O20

Mass

1851.31

PI

11.49

Net Charge

+2

Boman Index

-2.44

Hydrophobicity

1.463

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 108 µM

Target

Target Organism E.coli

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli (MIC 108 uM) and S. aureus (MIC 14 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 14 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

active against E.coli (MIC 108 uM) and S. aureus (MIC 14 uM).

Evidence 3 Activity

Activity

Activity Endpoint 48% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

48% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure and function of cationic hylin bioactive peptides from the tree frog Boana pulchella in interaction with lipid membranes. | Peptides | 2022

Evidence 4 Activity

Activity

Activity Endpoint 8% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

8% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Structure and function of cationic hylin bioactive peptides from the tree frog Boana pulchella in interaction with lipid membranes. | Peptides | 2022