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Peptide record

TPDB19160

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB19160
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
FKWKSVLKIVKIFVDIYF
Physicochemical Analysis
C117H177N23O23
ARNCEQGHMPT
K
2273.83
10.31
4
1
12
+3
-2.14
0.900
135.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
307.41
2
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
3
I
1
L
4
K
0
M
3
F
0
P
1
S
0
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 1 K: 4 M: 0 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 3
Chemical Descriptors
18
C117H177N23O23
2273.83
10.31
+3
-2.14
0.900
Evidence Records 1 records
Evidence 1 Activity

Activity

48.1 ± 5.2% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
48.1 ± 5.2% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo. | Eur J Med Chem | 2023