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Peptide record

TPDB19118

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19118
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and CAFPdb, with an available 3D structural model.
Sequence
FKRIVQLLKKLLR
Physicochemical Analysis
C79H143N23O15
ANDCEGHMPSTWY
L
1655.15
12.43
5
0
7
+5
1.56
0.192
172.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
4
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 4 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C79H143N23O15
1655.15
12.43
+5
1.56
0.192
Evidence Records 6 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
411 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 411 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
23.7 µg/mL
Cytotoxic
IC50 | 23.7 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
185 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 185 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
17.3 µg/mL
Cytotoxic
IC50 | 17.3 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 5 Activity

Activity

HC50
Toxicity
411 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=411 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=23.7 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.
Evidence 6 Activity

Activity

HC50
Toxicity
185 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=185 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=17.3 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.