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Peptide record

TPDB19117

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB19117
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 CAFPdb
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, and CAFPdb, with an available 3D structural model.
Sequence
FKRIVQLIKDFLR
Physicochemical Analysis
C80H134N22O17
ANCEGHMPSTWY
RILKF
1676.08
11.47
4
1
7
+3
1.48
0.200
142.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
1
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13
C80H134N22O17
1676.08
11.47
+3
1.48
0.200
Evidence Records 6 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
114 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 114 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
23.5 µg/mL
Cytotoxic
IC50 | 23.5 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
227 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 227 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
22.5 µg/mL
Cytotoxic
IC50 | 22.5 | µg/mL | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Cationic amphipathic peptide analogs of cathelicidin LL-37 as a probe in the development of antimicrobial/anticancer agents. | J Pept Sci | 2020
Evidence 5 Activity

Activity

HC50
Toxicity
114 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=114 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=23.5 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.
Evidence 6 Activity

Activity

HC50
Toxicity
227 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=227 µg/ml | Cytotoxicity: DLF lung fibroblasts: IC50=22.5 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Jul 26(7):e3254.